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O'Leary Lab - Publications

1. O'Leary, DDM, Fricke, RA, Stanfield, BB, Cowan, WM 1979 Changes in the associational afferents to the dentate gyrus in absence of its commissural input. Anatomy and Embryology 156: 283-299.

 2. O'Leary, DDM, Stanfield, BB, Cowan, WM 1980 Evidence for the sprouting of the associational fibers to the dentate gyrus following removal of the commissural afferents in adult rats. Anatomy and Embryology 156: 151-161.

 3. O'Leary, DDM, Stanfield, BB, Cowan, WM 1981 Evidence that early postnatal restriction of the cells of origin of the callosal projection is due to the elimination of axonal collaterals rather than to the death of neurons. Developmental Brain Research 1:607-617.

 4. Stanfield, BB, O'Leary, DDM, Fricks, C 1982 Selective collateral elimination in early postnatal development restricts cortical distribution of rat pyramidal tract neurones. Nature 298: 371-373.

5. Gerfen, CR, O'Leary, DDM, Cowan, WM 1982 A note on the transneuronal transport of wheat germ agglutinin conjugated horseradish peroxidase in the avian and rodent visual systems. Experimental Brain Research 48: 443-448.

6. O'Leary, DDM, Cowan, WM 1982 Further studies on the development of the isthmo-optic nucleus with special reference to the occurrence and fate of ectopic and ipsilaterally projecting neurons. Journal of Comparative Neurology 212: 399-416.

7. Swanson, LW, Lindstrom, J, Tzartos, S, Schmued, LC, O'Leary, DDM, Cowan, WM 1983 Immunohistochemical localization of monoclonal antibodies to the nicotinic acetylcholine receptor in the midbrain of the chick. Proc. Natl. Acad. Sci. USA 80: 4532-4536.

8. O'Leary, DDM, Gerfen, CR, Cowan, WM 1983 The development and restriction of the ipsilateral retinofugal projection in the chick. Developmental Brain Research 10: 93-109.

9. O'Leary, DDM, Cowan, WM 1983 Topographic organization of certain tectal afferent and efferent connections can develop normally in the absence of retinal input. Proc. Natl. Acad. Sci. USA 80: 6131-6135.

10. O'Leary, DDM, Cowan, WM 1984 Survival of isthmo-optic neurons after early removal of one eye. Developmental Brain Research 12: 293-310.

11. Fawcett, JW, O'Leary, DDM, Cowan, WM 1984 Activity and the control of ganglion cell death in the rat retina. Proc. Natl. Acad. Sci. USA 81: 5589-5593.

 12. Cowan, WM, Fawcett, JW, O'Leary, DDM, Stanfield, BB 1984 Regressive events in neurogenesis. Science 225: 1258-1265.

 13. Cowan, WM, O'Leary, DDM 1984 Cell death and process elimination: the role of regressive phenomena in the development of the vertebrate nervous system. In: Medicine, Science and Society: Symposia Celebrating the Harvard Medical School Bicentennial, K.J. Isselbacher (ed.), Wiley Press: New York, pp. 643-668.

 14. Stanfield, BB, O'Leary, DDM 1985 Fetal occipital cortical neurons transplanted to rostral cortex develop and maintain a pyramidal tract axon. Nature 313: 135-137.

15. Crespo, D, O'Leary, DDM, Cowan, WM 1985 Changes in the number of optic nerve axons during late prenatal and postnatal development of the albino rat. Developmental Brain Research 19: 129-134.

 16. O'Leary, DDM, Stanfield, BB 1985 Occipital cortical neurons with transient pyramidal tract axons extend and maintain collaterals to subcortical but not intracortical targets. Brain Research 336: 326-333.

 17. Stanfield, BB, O'Leary, DDM 1985 The transient corticospinal projection from the occipital cortex during the postnatal development of the rat. Journal of Comparative Neurology 238: 236-248.

18. Fawcett, JW, O'Leary, DDM 1985 The role of electrical activity in the formation of topographic maps. Trends in Neuroscience 8: 201-206.

 19. Cowan, WM, Fawcett, JW, O'Leary, DDM, Stanfield, BB 1985 Regressive events in neurogenesis. In: Neuroscience, P.H. Abelson, E. Butz, and S.H. Snyder (eds), Amer Assoc Adv Science, Washington D.C., pp.13-29.

 20. O'Leary, DDM, Stanfield, BB 1986 A transient pyramidal tract projection from the visual cortex in the hamster and its removal by selective collateral elimination. Developmental Brain Research 27: 87-99.

21. O'Leary, DDM, Crespo, D, Fawcett, JW, Cowan, WM 1986 The effect of intraocular tetrodotoxin on the postnatal reduction in numbers of optic nerve axons in the rat. Developmental Brain Research, 30: 96-103.

22. O'Leary, DDM, Fawcett, JW, Cowan, WM 1986 Topographic targeting errors in the retinocollicular projection and their elimination by selective ganglion cell death. Journal of Neuroscience6: 3692-3705.

 23. Stanfield, BB, Nahin, B, O'Leary, DDM 1987 A transient post-mammillary component of the rat fornix during development: implications for interspecific differences in mature axonal projections. Journal of Neuroscience 7: 3350-3361.

 24. Porter, LL, Cedarbaum, JM, O'Leary, DDM, Stanfield, BB, Asanuma, H 1987 The physiological identification of pyramidal tract neurons within transplants in the rostral cortex taken from the occipital cortex during development. Brain Research 436: 136-142.

 25. O'Leary, DDM 1987 The remodeling of early axonal projections through the selective loss of neurons and axon collaterals. In: Selective Neuronal Death, M. O'Connor (ed.), (Ciba Foundation Symposium No. 126), Wiley: Chichester, pp. 113-142.

 26. Stanfield, BB, O'Leary, DDM 1988 Neurons in the subiculum with transient postmammillary collaterals during development maintain projections to the mammillary complex. Experimental Brain Research 72: 185-190.

 27. O'Leary, DDM, Terashima, T 1988 Cortical axons branch to multiple subcortical targets by interstitial axon budding: implications for target recognition and "waiting periods." Neuron 1: 901-910.

 28. O'Leary, DDM, Stanfield, BB 1989 Selective elimination of axons extended by developing cortical neurons is dependent on regional locale. Experiments utilizing fetal cortical transplants. Journal of Neuroscience 9:2230-2246.

29. Nakamura, H, O'Leary, DDM 1989 Inaccuracies in initial growth and arborization of chick retinotectal axons followed by course corrections and axon remodeling to develop topographic order. Journal of Neuroscience 9:3776-3795.

30. O'Leary, DDM 1989 Do cortical areas emerge from a proto-cortex? Trends in Neuroscience 12:400-406.

31. Simon, DK, O'Leary, DDM 1990 Limited topographic specificity in the targeting and branching of mammalian retinal axons. Developmental Biology 137:125-134.

32. Heffner, CA, Lumsden, AGS, O'Leary, DDM 1990 Target control of collateral extension and directional axon growth in the mammalian brain. Science 247:217-220.

33. O'Leary, DDM, Bicknese, AR, De Carlos, JA, Heffner, CD, Koester, SE, Kutka, LJ, Terashima, T 1990 Target selection by cortical axons: Alternative mechanisms to establish axonal connections in the developing brain. Cold Spring Hbr Symp Quant Biol. 55:453-468.

34. O'Leary, DDM 1990 Growth, branching, and target selection by developing cortical axons. In: FESN Symp #8: Neural Development, T Wiesel, L Katz and D Anderson (Eds.), Elsevier: Amsterdam.

35. Simon, DK, O'Leary, DDM 1991 Relationship of retinotopic ordering of axons in the optic pathway to the formation of visual maps in central targets. Journal of Comparative Neurology 307:393-404.

36. Schlaggar, BL, O'Leary, DDM 1991 Potential of visual cortex to develop arrays of functional units unique to somatosensory cortex. Science 252:1556-1560.

37. O'Leary, DDM, Heffner, CD, Kutka, L, Lopez-Mascaraque, L, Missias, A, Reinoso, BS 1991 A target-derived chemoattractant controls the development of the corticopontine projection by a novel mechanism of axon targeting. Development  2:123-130.

38. O'Leary, DDM, Schlaggar, BL, Stanfield, BB 1992 The specification of sensory cortex: Lessons from cortical transplantation. Experimental Neurology 115:121-126.

39. Simon, DK, O'Leary, DDM 1992 Development of topographic order in the mammalian retinocollicular projection. Journal of Neuroscience 12:1212-1232.

40. De Carlos, JA, O'Leary, DDM 1992 Growth and targeting of subplate axons and establishment of major cortical pathways. Journal of Neuroscience 12:1194-1211.

41. Koester, SE, O'Leary, DDM 1992 Functional classes of cortical projection neurons develop dendritic distinctions by class-specific sculpting of an early common pattern. Journal of Neuroscience 12:1382-1394.

42. Simon, DK, O'Leary, DDM 1992 Influence of position along the medial-lateral axis of the superior colliculus on the topographic targeting and survival of retinal axons. Developmental Brain Research 69:167-172.

43. Simon, DK, Prusky, GT, O'Leary, DDM, Constantine-Paton, M 1992 NMDA receptor antagonists disrupt the development of a mammalian neural map. Proc. Natl. Acad. Sci. USA, 89:10593-10597.

44. Simon, DK, O'Leary, DDM 1992 Responses of retinal axons in vivo and in vitro to molecules encoding position in the embryonic superior colliculus. Neuron 9:977-989.

 45. O'Leary, DDM 1992 Development of connectional diversity and specificity in the mammalian brain by the pruning of collateral projections. Current Opinion in Neurobiology 2:70-77.

46. O'Leary, DDM, Simon, DK 1992 Position-encoding molecules and the development of retinal maps. Seminars in Neuroscience 4:365-371.

 47. Schlaggar, BL, De Carlos, JA, O'Leary, DDM 1993 Acetylcholinesterase as an early marker of the differentiation of dorsal thalamus in embryonic rats. Developmental Brain Research 75:19-30.

 48. Schlaggar, BL, Fox, K, O'Leary, DDM 1993 Postsynaptic control of plasticity in developing somatosensory cortex. Nature 364:623-626.

 49. Koester, SE, O'Leary, DDM 1993 Connectional distinction between callosal and subcortically projecting cortical neurons is determined before axon extension. Developmental Biology 160:1-14.

 50. Tuttle, R, O'Leary, DDM 1993 Cortical connections form in culture. Current Biology 3:70-72.

 51. O'Leary, DDM 1993 Adding neurons to the adult mammalian brain. Proc Natl Acad Sci USA 90:2101-2102.

 52. O'Leary, DDM, Koester, SE 1993 Development of projection neuron types, axonal pathways and patterned connections of the mammalian cortex. Neuron 10:991-1006.

 53. Schlaggar, BL, O'Leary, DDM 1993 Patterning of the barrelfield in somatosensory cortex with implications for the specification of neocortical areas. Perspectives on Developmental Neurobiology 1:81-92.

54. Shatz, CJ, O'Leary, DDM for the panel. 1993 Repair and replacement to restore sight report from panel on ganglion cell connectivity. Archs. Opthalmol., 111:472-477.

55. Simon, DK, Roskies, AL, O'Leary, DDM 1994 Plasticity in the development of topographic order in the mammalian retinocollicular projection. Developmental Biology 162:384-393.

56. Bicknese, AR, Sheppard, AM, O'Leary, DDM, Pearlman, AL 1994 Thalamocortical axons extend along a chondroitin sulfate proteoglycan-enriched pathway coincident with the neocortical subplate and distinct from the efferent path. Journal of Neuroscience 14:3500-3510.

57. Schlaggar, BL, O'Leary, DDM 1994 Early development of the somatotopic map and barrel patterning in rat somatosensory cortex. Journal of Comparative Neurology 346:80-96.

58. Roskies, A, O’Leary, DDM 1994 Control of topographic retinal axon branching by inhibitory membrane-bound molecules. Science 265:799-802.

59. Sato, M, Lopez-Mascaraque, L, Heffner, CD, O’Leary, DDM 1994 Action of a diffusible target-derived chemoattractant on cortical axon branch induction and directed growth. Neuron 13:791-803.

 60. Koester, SE, O'Leary, DDM 1994 The corpus callosum is pioneered by early generated neurons of the cingulate cortex. Journal of Neuroscience 14:6608-6621.

 61. O'Leary, DDM, Schlaggar, BL, Tuttle, R 1994 Specification of neocortical areas and thalamocortical connections. Annual Review of Neuroscience 17: 419-439.

62. Lumsden, AGS, O’Leary, DDM 1994 Development: editorial overview. Current Opinion in Neurobiology 4: 1-7.

 63. O’Leary, DDM, Ruff, NL, Dyck, RL 1994 Development, critical period plasticity, and adult reorganizations of mammalian somatosensory systems. Current Opinion in Neurobiology 4: 535-544.

64. O’Leary, DDM 1994 Attractive guides for axons. Nature 371:15-16.

 65. Koester, SE, O’Leary, DDM 1994 Development of projection neurons in mammalian cerebral cortex. Progress in Brain Research102:207-215.

 66. Tuttle, R, Braisted, J, Schlaggar, BL, O'Leary, DDM 1995 Maturation-dependent upregulation of growth promoting molecules in developing cortical plate controls thalamic and cortical neurite growth. Journal of Neuroscience 15:3039-3052.

 67. De Carlos, JA, Schlaggar, BL, O'Leary, DDM 1995 Development of acetylcholinesterase-positive thalamocortical and basal forebrain afferents to embryonic rat cortex. Experimental Brain Research 104:385-401.

68. Roskies, A, Friedman, G, O'Leary, DDM 1995 Molecules and mechanisms in the development of retinotopic maps. Perspectives on Developmental Neurobiology 3:63-75.

 69. O’Leary, DDM, Borngasser, DJ, Fox, K, Schlaggar, BL 1995 Plasticity in the development of neocortical areas. In: Development of the Cerebral Cortex. Ciba Fnd Symp No. 193. G. Bock and C. Blakemore, Eds. pp.214-230.

 70. Bastmeyer, M, O’Leary, DDM 1996 Dynamics of target recognition by interstitial axon branching along developing cortical axons. Journal of Neuroscience 16:1450-1459.

 71. Moriyoshi, K, Richards, L, Akazawa, C, O'Leary, DDM, Nakanishi, S 1996 Labeling neural cells using adenoviral gene transfer of membrane-targeted GFP. Neuron 16:255-260.

 72. Fox, K, Schlaggar, BL, O’Leary, DDM 1996 Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization of somatosensory cortex. Proc. Natl. Acad. Sci. USA 93:5584-5589.

73. Friedman, GC, O’Leary, DDM 1996 Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons. Journal of Neuroscience 16:5498-5509.

 74. Daston, MM, Bastmeyer, M, Rutishauser, U, O’Leary, DDM 1996 Spatially restricted increase in polysialic acid influences target recognition by corticospinal axons. Journal of Neuroscience 16:5488-5497.

75. Nakamoto, M, Cheng, H-J, Friedmann, GC, McLaughlin, T, Hansen, MJ, Yoon, CH, O'Leary, DDM, Flanagan, JG 1996 Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell 86:755-766.

 76. O’Leary, DDM 1996 Areal specialization of the developing neocortex: differentiation, developmental plasticity and genetic specification. In: Nobel Symposium: The Lifespan Development of Individuals -Behavioral, Neurobiological and Psychosocial Perspectives. D. Magnusson, Ed., Elsevier Press. pp.23-37.

77. Friedman, GC, O’Leary, DDM 1996 Eph receptor tyrosine kinases and their ligands in neural development. Current Opinion in Neurobiology 6:127-133.

 78. O’Leary, DDM, Bastmeyer, M, Daston, ME, Koester, SE, Richards, L, Yee, K 1996 Development of Cortical Output Projections: Axon Guidance, Target Recognition, and Plasticity. In: Integrative and Molecular Approach to Brain Function: Uehara Memorial Foundation Symposium-1996. M. Ito and Y. Miyashita, Eds. Elseveir:Amsterdam. pp.165-178.

 79. Richards, LR, Koester, SE, Tuttle, R, O’Leary, DDM 1997 Directed growth of early cortical axons is influenced by a chemoattractant released from an intermediate target. Journal of Neuroscience 17:2445-2458.

80. Braisted, JE, McLaughlin, T, Wang, HU, Friedman, GC, Anderson, DJ, O'Leary, DDM 1997 Graded and lamina-specific distributions of ligands of EphB receptor tyrosine kinases in the developing retinotectal system. Developmental Biology 191:14-28.

 81. Chenn, A, Braisted, JE, McConnell, SK, O’Leary, DDM 1997 Development of the Cerebral Cortex: Mechanisms Controlling Cell Fate, Laminar and Areal Patterning, and Axonal Connectivity. In, Molecular and Cellular Approaches to Neural Development, pp. 440-473. Oxford Univ. Press. W.M. Cowan, L. Zipursky, and T. Jessell, Eds.

 82. Bastmeyer, B, Daston, MM, Possel, H, O’Leary, DDM 1998 Collateral branch formation        related to cellular structures in the axon tract during corticopontine target recognition. Journal of Comparative Neurology 392:1-18.

83. Tuttle, R, Braisted, JE, Richards, LJ, O’Leary, DDM 1998 Retinal axon guidance by region specific cues in the diencephalon. Development 125:791-801.

84. Frisén J1, Yates PA1, McLaughlin T, Friedman GC, O'Leary DDM2, Barbacid M2 1998 Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron 20:235-243. [1, co-first authors; 2, co-communicating authors]

85. Tuttle, R, O’Leary, DDM 1998 Neurotrophins rapidly modulate growth cone response to the axon guidance molecule, collapsin-1. Mol Cell Neurobio 11:1-8.

 86. Braisted, JE, Tuttle, R, O’Leary, DDM 1999 Thalamocortical axons are influenced by chemorepellent and chemoattractant activities localized to decision points along their path. Developmental Biology 208:430-440.

 87. Tuttle, R1, Nakagawa, Y1, Johnson, JE, O'Leary, DDM 1999 Defects in thalamocortical axon pathfinding correlate with altered cell domains in embryonic Mash-1 deficient mice. Development 126:1903-1916. [1, co-first authors]

88. O’Leary, DDM, Wilkinson, DG 1999 Eph receptors and ephrins in neural development. Current Opinion in Neurobiology9:55-73.

89. O’Leary, DDM, Yates, P, McLaughlin, T, 1999 Mapping sights and smells in the brain: Distinct mechanisms to achieve a common goal. Cell 96:255-269.

90. McLaughlin, T, O’Leary, DDM 1999 Functional consequences of coincident expression of EphA receptors and ephrin-A ligands. Neuron 22:636-639.

 91. Bertuzzi, S, Hindges, R, Mui, S, O’Leary, DDM, Lemke, G 1999 The homeodomain protein Vax1 is required for axon guidance and development of major axon tracts in the brain. Genes and Development 13:3092-3105.

92. Yee, KT, Simon, HH, Tessier-Lavigne, M, O’Leary, DDM 1999 Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1. Neuron 24:607-622.

 93. Nakagawa, Y, Johnson, JE, O’Leary, DDM 1999 Graded and areal expression patterns of regulatory genes and cadherins in embryonic neocortex independent of thalamocortical input. Journal of Neuroscience 19:10877-10885.

 94. Bishop, KM, Goudreau, G, O'Leary, DDM 2000 Emx2 and Pax6 regulate area identity in the mammalian neocortex. Science 288:344-349.

95. Ringstedt, T1, Braisted, JE1, Brose, K, Goodman, C, Kidd, T, Tessier-Lavigne, M, O’Leary, DDM 2000 Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns within the diencephalon Journal of Neuroscience 20:4983-4991. [1, co-first authors]

96. Brown, A1, Yates, PA1, Burrola, P, Ortuño, D, Vaidya, A, Jessell, TM, Pfaff, SL, O’Leary, DDM2, Lemke, G2 2000 Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling. Cell 102:77-88. [1, co-first authors; 2, co-senior  authors].

 97. Braisted, JE, Catalano, SM, Stimac, R, Kennedy, T, Tessier-Lavigne, M, Shatz, CJ, O’Leary, DDM 2000 Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. Journal of Neuroscience 20:5792-5801.

 98. Liu, Q1, Dwyer, ND1, O'Leary, DDM 2000 Differential expression of COUP-TF1, CHL-1 and two novel genes in developing neocortex identified by differential display PCR. Journal of Neuroscience 20:7682-7690. [1, co-first authors]

99. Erkman, L, Yates, PA, McLaughlin, T, McEvilly, RJ, Whisenhunt, T, O’Connell, SM, Krones, AL, Kirby, MA, Rapaport, DH, Bermingham, JR, O’Leary, DDM1, Rosenfeld, MG1 2000 A POU domain transcription factor dependent program regulates axon pathfinding in the vertebrate visual system. Neuron 28:779-792. [1, co-communicating authors]

100. Dwyer, ND, O’Leary, DDM 2001 Tbr1 conducts the orchestration of early cortical development. Neuron 29:309-311.

101. Nakagawa, Y, O’Leary, DDM  2001 Combinatorial patterns of expression of LIM-homeodomain and other regulatory genes parcellate developing thalamus. Journal of Neuroscience, 21:2711-2725.

102. Simon, HH, Saueressig, H, Wurst, W, Goulding, MD, O'Leary, DDM  2001 Fate of midbrain dopaminergic neurons controlled by the engrailed genes. Journal of Neuroscience, 21:3126-3134.

103. Gesemann, M1, Litwack, ED1, Yee, KT, O’Leary, DDM  2001 Identification of candidate genes for controlling development of the basilar pons by differential display PCR. Mol Cell Neurobio 18:1-12. [1, co-first authors]

104. Yates, PA1, Roskies, AR1, McLaughlin, T, O’Leary, DDM  2001 Topographic specific axon branching controlled by ephrin-As is the critical event in retinotectal map development. Journal of Neuroscience, 21:8548-8563. [1, co-first authors]

105. Mui, SH, Hindges, R, O'Leary, DDM, Lemke, G, Bertuzzi, S 2002 The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development 129:797-804.

106. O’Leary, DDM, Nakagawa, Y 2002 Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex. Curr. Op. Neurobio.,12:14-25.

107. Woodring, PJ, Litwack, ED, O’Leary, DDM, Lucero, GR, Wang, JYJ, Hunter, T 2002 Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. Journal of Cell Biology, 156:879-892.

108. Hindges, R1, McLaughlin, T1, Genoud, N, Henkemeyer, M, O’Leary, DDM 2002 EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. Neuron, 35: 475-487. [1, co-first authors]

109. Bishop, KM, Rubenstein JRL, O'Leary, DDM 2002 Distinct actions of Emx1, Emx2 and Pax6 in regulating the specification of areas in the developing neocortex. Journal of Neuroscience, 22:7627-7638.

110. Burden, S, Berg, D, O’Leary, DDM 2003 Chapter 18: Target Selection, Topographic Maps, and Synapse Formation. pp. 469-498. In: Fundamentals of Neuroscience, 2nd Edition. (Squire, Bloom, McConnell, Roberts, Spitzer, Zigmond, eds.). Academic Press.

111. McLaughlin, T, Hindges, R, O’Leary, DDM 2003 Regulation of axial patterning of the retina and its topographic mapping in the brain. Curr Op Neurobio, 13:57-69.

112. Bishop, KM, Garel S, Nakagawa, Y, Rubenstein JRL, O'Leary, DDM 2003 Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. Journal of Comparative Neurology457:345-360.

113. McLaughlin, T, Hindges, R, Yates, PA, O’Leary, DDM 2003 Bifunctional action of ephrin-B1 as a repellent and attractant to control bidirectional branch extension in dorsal-ventral retinotopic mapping. Development 130:2407-2418.

114. Leingartner, A, Richards, LJ, Dyck, RH, Akazawa, C, O'Leary, DDM 2003 Cloning, patterned cortical expression, and adenovirus-mediated ectopic expression of Emx2 to assess its regulation of area-specific thalamocortical projections. Cerebral Cortex 13:648-660.

115. Nakagawa Y, O’Leary DDM 2003 Dynamic patterned expression of orphan nuclear receptor genes RORa and RORbin developing mouse forebrain. Developmental Neuroscience, 25:234-244.

116. McLaughlin, T1, Torborg, CL1, Feller, MB2, O’Leary, DDM2 2003 Retinotopic map refinement requires spontaneous retinal waves during a brief critical period of development. Neuron, 40:1147-1160. [1, co-first authors; 2, co-communicating authors]

117. Yates, PA, Holub, AD, McLaughlin, T, Sejnowski, TJ, O’Leary, DDM 2004 Computational modeling of retinotopic map development to define contributions of EphA-ephrin-A gradients, axon-axon interactions and patterned activity. Journal of Neurobiology59:95-113.

118. Litwack, ED, Babey, R, Buser, R, Gesemann, M, O’Leary, DDM 2004 Identification and characterization of two novel brain-derived immunoglobulin superfamily members that display a unique structural organization. Mol Cell Neurobio, 25:263-274.

119. Thuret, S, Bhatt, L, O’Leary, DDM, Simon, HH 2004Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Mol Cell Neurobio, 25:394-405.

120. Hamasaki, T1, Leingartner, A1, Ringstedt, T, O’Leary DDM  2004 . Neuron 43:359-72. [1, co-first authors]

121. Pak, W, Hindges, R, Lim, Y-S, Pfaff, SL, O’Leary, DDM 2004 Magnitude of binocular vision controlled by Islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding. Cell 119:567-578.

122. O'Leary, DDM, McLaughlin, T 2005 Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity. In: Development, Dynamics and Pathology of Neuronal Networks: From Molecules to Functional Circuits, J. van Pelt, M. Kamermans, C.N. Levelt, A. van Ooyen, G.J.A. Ramakers, P.R. Roelfseman (Eds.), Progress in Brain Research Vol. 147. Elsevier, Amsterdam, pp. 43 - 65.

123. Simon, HH, Scholtz, C, O’Leary, DDM 2005 Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner.  Mol Cell Neurobio  28:96-105.

124. McLaughlin, T, O’Leary, DDM 2005 Molecular gradients and development of retinotopic maps. Annual Review of Neuroscience 28:327-356.

125. Luo, L., O’Leary, DDM 2005 Axon retraction and degeneration in development and disease. Annual Review of Neuroscience 28:127-156.

126. Kroll, TT, O’Leary, DDM 2005 Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate. Proc. Natl. Acad. Sci. USA 102:7374-7379.

127. Quina, L, Pak, W, Lanier J, Banwait P, Gratwick K, Liu L, Velasquez T, O’Leary DDM, Goulding M, Turner EE  2005 Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. Journal of Neuroscience 25:11595-11604.

29. O’Leary DDM, Borngasser D 2006 Cortical progenitors and progeny maintain spatial relationships and radial patterning during preplate development indicating an early protomap. Cerebral Cortex 16:i46-i56.

130. Hoopfer, ED1, McLaughlin, T1, Watts, RJ, Schuldiner, O, O’Leary, DDM2, Luo, L2 2006
Wlds protection distinguishes axon degeneration following injury from naturally-occurring developmental pruning. Neuron 50:883-895. [1, co-first authors; 2, co-communicating authors]

131. Li, H1, Bishop, KM1, O’Leary, DDM  2006 Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci, 33:136-149. [1, co-first authors]

132. Leingartner, A1, Thuret, S1, Kroll, TT, Chou, S-J, Leasure, JL, Gage, FH, O’Leary, DDM 2007 Sizes of somatosensory and motor cortical areas determine proficiency at tactile and motor behaviors. Proc. Natl. Acad. Sci. USA, 104:4153-4158. [1, co-first authors]

133. Takeuchi, A1, Hamasaki, T1, Litwack, ED, O’Leary DDM  2007 Novel IgCAM, MDGA1, expressed in unique cortical area- and layer-specific patterns and transiently by distinct forebrain populations of Cajal-Retzius neurons. Cerebral Cortex, 17:1531-1541. [1, co-first authors]

134. Sahara, S, Kawakami, Y, Izpisua Belmonte, JC, O’Leary, DDM  2007 Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. Neural Development, 2:10  doi:10.1186/1749-8104-2-10

135. Burden, S, O’Leary, DDM, Scheiffele, P.  2007 Chapter 18: Target Selection, Topographic Maps, and Synapse Formation. pp. 469-498. In: Fundamentals of Neuroscience, 3rd Edition. (L. Squire, ed.). Academic Press.

136. Armentano, M1, Chou, S-J1, Tomassy, GS, Leingärtner, A, O’Leary, DDM2, Studer, M2  2007
COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas.
Nature Neuroscience 10:1277-1286. [1, co-first authors; 2, co-communicating authors]

137. O’Leary, DDM, Chou, S-J, Hamasaki, T, Sahara, S, Takeuchi, A, Thuret, S, Leingartner, A  2007 Regulation of laminar and area patterning of mammalian neocortex and behavioural Implications. In: Development of the Cerebral Cortex. Novartis Foundation Symposium. G. Bock, J. Goode, Eds. Oxford Press. pp.141-164.

138. O’Leary, DDM, Chou, S-J, Sahara, S  2007 Area patterning of the mammalian cortex. Neuron, 56:252-269.

139. Zhou, L, Bar, I, Achouri, Y, Campbell, K, De Backer, O, Hebert, J, Jones, K, Kessaris, N, Lambert de Rouvroit, C, O’Leary, DDM, Richardson, W, Goffinet, A, Tissir, F  2008 Early Forebrain Wiring: Genetic Dissection Using Conditional Celsr3 Mutant Mice. Science 320: 946 – 949.

140. O’Leary, DDM, Sahara, S. 2008 Genetic regulation of arealization of the neocortex. Current Opinion in Neurobiology, 18:90-100.
142. Lim, Y-S1, McLaughlin, T1, Sung, T-C1, Santiago, A, Lee, K-F, O’Leary, DDM  2008  p75NTR mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron, 59:746-758. [1, co-first authors]

143. McLaughlin, T, O’Leary, DDM  2009 Chemoaffinity Hypothesis: Development of Topographic Axonal Projections.  In: Squire LR (ed.) Encyclopedia of Neuroscience, vol 2, pp. 819-825. Oxford: Academic Press.

144. O’Leary, DDM, Kroll, TK, 2009 Neural Patterning: Arealization of the Cortex. In: Squire LR (ed.) Encyclopedia of Neuroscience, vol 2, pp. 189-197. Oxford: Academic Press.

145. Nikolaev, A, McLaughlin, T, O’Leary, DDM,  Tessier-Lavinge, M  2009 APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981-990.

146. Braisted, JE1, Ringstedt, T1, O’Leary, DDM  2009 Slits are chemorepellents endogenous to hypothalamus and steer thalamocortical axons into ventral telencephalon. Cerebral Cortex, in press. [1, co-first authors]

147. Sahara, S, O’Leary, DDM   2009  Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors.  Neuron, in press.

148. Chou, S-J, Perez-Garcia, CG, Kroll, TT, O’Leary, DDM 2009 Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nature Neurosci. 12:1381-1389.

149. Feldheim, DA, O’Leary, DDM 2010 Visual Map Development: Bidirectional Signaling, Bifunctional Guidance Molecules, and Competition. Cold Spring Harbor Perspectives in Biology. Web Pub Date 09-29-10. PMID: 20880989

150. Wu, CS, Zhu, J, Wager-Miller, J, Wang, S, O’Leary, DDM, Monory, K, Lutz, B, Mackie, K, Lu, HC 2010 Requirement of cannabinoid CB1 receptor in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur. J. of Neuroscience 32:693-706.

151. Dwyer, ND, Manning, DK, Moran, JL, Mudbhary, R, Fleming, MS, O'Leary, DDM, Walsh, CA, Beier, DR. 2011 A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct Emx2 mutant phenotype. Neural Development, 6:3.

152. Kawakami, Y, Marti, M, Kawakami, H, Itoh, J, Quach, T, Johnson, A, Sahara, S, O'Leary, DDM, Nakagawa, Y, Lewandoski, M, Pfaff, S, Evans, S, Izpisua Belmonte, JC  2011  Islet1-mediated activation of the ß-catenin pathway is necessary for hindlimb initiation in mice.  Development, in press.

153. Hurtado de Mendoza, T, Perez-Garcia, CG, Kroll T, Hoong, N, O'Leary, DDM, Verma, I. 2011 Lifeguard: An Anti-Apoptotic Protein Required for Survival and Maintenance of Purkinje and Granular Cells. PNAS, In press.

154. Sahara, S, Yanagawa, Y, O’Leary, DDM1, Stevens, CF 2011 Fraction of cortical inhibitory neurons is constant from early cortical neurogenesis to adulthood. Journal of Neuroscience (Final Revision, Provisionally Accepted). [1, communicating author]

155. Li, H, Chou, S-J, Hamasaki T, Perez-Garcia, CG, O’Leary, DDM 2011 Neuregulin repellent signaling via ErbB4 funnels migrating GABAergic interneurons from ganglionic eminence to cortical destinations. Neural Development, Reviewed, being revised.

156. Simon, DJ, Weimer, RM, McLaughlin, T, Kallop, D, Stanger, K, Yang, J, O’Leary, DDM, Hannoush, RN, Tessier-Lavigne, M. 2011 The caspase cascade of axon degeneration. Submitted.

157. Chou, S-J, O’Leary, DDM  2011  Role for Lhx2 in corticogenesis through regulation of progenitor differentiation. Submitted.

158. Pao, G, Zhu, Q, Perez-Garcia, C, Chou, S-J, Suh, H, Gage, FH, O’Leary, DDM, Verma, IM  2011  A role of tumor suppressor BRCA1 in embryonic brain development and neurogenesis Submitted.

159. Lu, HC, Ballester-Rosado, C, Albright, M, Wu, CS, Liao, C-C, Zhu, J, Xu, J, Chou, S-J, O’Leary, DDM, Lee, L-J. 2011 mGluR5 in cortical excitatory neurons exerts both cell autonomous and nonautonomous influences on cortical somatosensory circuit formation. Reviewed, being revised.

To be submitted soon

160. Zembrzycki, A, Chou, S-J, Ashery-Padan, R, Stoykova, A, O’Leary DDM 2011 Intrinsic regulation of somatosensory cortical field size limits representation of sensory periphery and drives corticothalamic plasticity.

161. Sahara, S, Klein, R, O’Leary, DDM. Cortical areal distribution of GABAergic interneurons determined by EphB1-ephrin-B1 repellent signaling through interactions with radial glia.

162. Leingartner, A, Chou, S-J, Hamasaki, T, Kalatsky, V, Cang, J, Stryker, MP, O’Leary, DDM 2011 Absolute levels of EMX2 in cortical progenitors determines complete repertoire of area-specific properties of cortical neurons.